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centromere protein U (CENP-U, CENP-U50, CENP-50, interphase centromere complex protein 24, MLF1-interacting protein, KSHV latent nuclear antigen-interacting protein 1, MLF1IP, CENPU, ICEN24, KLIP1)
Function:
1) component of the CENPA-NAC
2) also involved in transcriptional repression
3) interacts with MLF1
Compartment:
- cytoplasm, nucleus, kinetochore
- localizes in the kinetochore domain of centromeres
Alternative splicing: named isoforms=2
Expression:
- expressed in testis, fetal liver, thymus, bone marrow > lymph nodes, placenta, colon & spleen
- present in B-cells, T-cells, epithelial cells, fibroblasts
Pathology:
1) interacts with the N-terminal domain of Kaposi's sarcoma- associated herpesvirus latent nuclear antigen
2) expressed at high levels in glioblastoma cell lines
General
nuclear protein
phosphoprotein
Properties
SIZE: MW = 48 kD
entity length = 418 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: nuclear translocation signal {6-23}
Ser phosphorylation site {S94}
Ser phosphorylation site {S229}
coiled coil {297-356}
MOTIF: nuclear translocation signal {303-320}
coiled coil {397-417}
Database Correlations
UniProt Q71F23
References
UniProt :accession Q71F23
Component-of
CENPA-NAC (nucleosome-associated) complex