centromere protein K (CENP-K, interphase centromere complex protein 37, protein AF-5alpha, p33, CENPK, ICEN37, FKSG14)

Function: - component of the CENPA-CAD complex Compartment: - nucleus, centromere - localizes exclusively in the centromeres Expression: - expressed in several fetal organs with highest levels in fetal liver - in adults, it is weakly expressed in lung, placenta Pathology: 1) chromosomal aberrations involving CENPK are a cause of acute leukemias 2) chromosomal translocation t(5;11)(q12;q23) with MLL

General

nuclear protein phosphoprotein

Properties

SIZE: MW = 32 kD entity length = 269 aa COMPARTMENT: cell nucleus MOTIF: coiled coil {22-42} coiled coil {98-151} phosphorylation site

References

UniProt :accession Q9BS16