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centralspindlin complex
Function:
- microtubule-dependent & Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis
Structure:
- subunits include: RACGAP1 & KIF23
- heterotetramer of two molecules each of RACGAP1 & KIF23
General
molecular complex
Properties
SUBUNITS: Rac GTPase-activating protein 1
COMPARTMENT: cytoplasm
cell nucleus
golgi
MOTIF: coiled coil {53-110}
SLC26A8 interaction {106-285}
MOTIF: Ser phosphorylation site {S144}
Thr phosphorylation site {T145}
Ser phosphorylation site {S149}
Ser phosphorylation site {S154}
Ser phosphorylation site {S157}
Thr phosphorylation site {T161}
Ser phosphorylation site {S164}
Ser phosphorylation site {S170}
Ser phosphorylation site {S185}
Ser phosphorylation site {S187}
Ser phosphorylation site {S203}
Ser phosphorylation site {S206}
Ser phosphorylation site {S214}
Ser phosphorylation site {S257}
Thr phosphorylation site {T260}
Zinc finger
NAME: Zinc finger
SITE: 286-335
EFFECTOR-BOUND: Zn+2
Thr phosphorylation site {T342}
rho-GAP domain
NAME: rho-GAP domain
SITE: 349-539
MOTIF: Ser phosphorylation site {S387}
Ser phosphorylation site {S573}
Thr phosphorylation site {T580}
Thr phosphorylation site {T588}
Ser phosphorylation site {S590}
Ser phosphorylation site {S591}
Ser phosphorylation site {S592}
Ser phosphorylation site {S593}
Ser phosphorylation site {S600}
Thr phosphorylation site {T601}
Thr phosphorylation site {T606}
Ser phosphorylation site {S628}
kinesin-like protein 1
COMPARTMENT: cell nucleus
MOTIF: kinesin motor domain
SITE: 1-352
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 112-119
binding site
FOR-BINDING-OF: microtubule
nuclear translocation signal {7-11}
Tyr phosphorylation site {Y29}
Ser phosphorylation site {S155}
Ser phosphorylation site {S160}
Thr phosphorylation site {T450}
coiled coil {535-620}
Ser phosphorylation site {S682}
Ser phosphorylation site {S684}
Ser phosphorylation site {S686}
Thr phosphorylation site {T738}
Ser phosphorylation site {S814}
Ser phosphorylation site {S867}
Ser phosphorylation site {S902}
Ser phosphorylation site {S911}
Ser phosphorylation site {S912}
References
UniProt :accession Q9H0H5
Components
mitotic kinesin-like protein 1 (kinesin-like protein KIF23, kinesin-like 5 protein, KNSL5, KIF23, MKLP1)
Rac GTPase-activating protein 1; male germ cell Racgap; MgcRacGAP; protein CYK4 homolg; CYK4; HsCYK-4 (RACGAP1, KIAA1478, MGCRACGAP)