Search
centaurin-gamma-3; Arf-GAP with GTPase, ANK repeat & PH domain-containing protein 3; AGAP-3; CRAM-associated GTPase; CRAG; Cnt-g3; MR1-interacting protein; MRIP-1 (AGAP3, CENTG3)
Function:
- GTPase-activating protein for the ADP ribosylation factor family (putative)
- GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway
- GTPase activity is stimulated by oxidative stress
- interacts with PML
- interacts with expanded polyglutamine proteins
Structure:
- belongs to the centaurin gamma-like family
- contains 3 ANK repeats
- contains 1 Arf-GAP domain
- contains 1 PH domain
Compartment:
- cytoplasm
- in cells upon oxidative stress or in brains of Machado-Joseph disease patients, translocates to PML nuclear bodies
Alternative splicing: named isoforms=4
Expression: widely expressed
Related
pleckstrin homology [PH] domain
pleckstrin; platelet p47 protein (PLEK P47)
General
ankyrin repeat domain protein (ANKRD)
centaurin gamma
phosphoprotein
Properties
SIZE: entity length = 875 aa
MW = 95 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Small GTPase-like {84-375}
MOTIF: GTP-binding site
SITE: 98-105
GTP-binding site
SITE: 142-146
GTP-binding site
SITE: 198-201
Thr phosphorylation site {T324}
Thr phosphorylation site {T326}
Ser phosphorylation site {S336}
PH domain {367-605}
MOTIF: Ser phosphorylation site {S443}
Arf-GAP domain
NAME: Arf-GAP domain
SITE: 626-746
MOTIF: Zn finger C4-type
SITE: 641-664
EFFECTOR-BOUND: Zn+2
ankyrin repeat
NAME: ankyrin repeat
SITE: 748-777
ankyrin repeat
NAME: ankyrin repeat
SITE: 785-814
ankyrin repeat
NAME: ankyrin repeat
SITE: 818-847
Database Correlations
UniProt Q96P47
PFAM correlations
Entrez Gene 116988
Kegg hsa:116988
References
UniProt :accession Q96P47