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centaurin-beta-2; Arf-GAP with coiled-coil, ANK repeat & PH domain-containing protein 2; Cnt-b2 (ACAP2, CENTB2, KIAA0041)
Function:
- GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6)
- GAP activity stimulated by phosphatidylinositol-4,5-bisphosphate (PIP2) & phosphatidic acid
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- contains 3 ANK repeats
- contains 1 Arf-GAP domain
- contains 1 BAR domain
- contains 1 PH domain
Expression:
- widely expressed
- highest level in lung
Related
pleckstrin homology [PH] domain
pleckstrin; platelet p47 protein (PLEK P47)
General
ankyrin repeat domain protein (ANKRD)
centaurin beta
phosphoprotein
Properties
SIZE: entity length = 778 aa
MW = 88 kD
COMPARTMENT: cytoplasm
MOTIF: BAR {1-226}
PH domain {266-361}
Ser phosphorylation site {S379}
Ser phosphorylation site {S384}
Arf-GAP domain
NAME: Arf-GAP domain
SITE: 399-520
MOTIF: Zn finger C4-type
SITE: 414-437
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S521}
ankyrin repeat
NAME: ankyrin repeat
SITE: 640-669
ankyrin repeat
NAME: ankyrin repeat
SITE: 673-702
ankyrin repeat
NAME: ankyrin repeat
SITE: 706-735
Tyr phosphorylation site {Y742}
Tyr phosphorylation site {Y750}
Ser phosphorylation site {S775}
Database Correlations
OMIM 607766
UniProt Q15057
PFAM correlations
Entrez Gene 23527
Kegg hsa:23527
References
UniProt :accession Q15057