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major centromere autoantigen B; centromere protein B; CENP-B (CENPB)

Function: - interacts with centromeric heterochromatin in chromosomes - binds to a specific subset of alphoid satellite DNA, called the CENP-B box - may organize arrays of centromere satellite DNA into a higher order structure which then directs centromere formation & kinetochore assembly in mammalian chromosomes Structure: - homodimer - contains 1 HTH CENPB-type DNA-binding domain - contains 1 HTH psq-type DNA-binding domain Compartment: nucleus, centromere Pathology: - autoantibody anti-centromere protein B antibody is seen in patients with cutaneous lupus erythematosus [3] Laboratory: - centromere protein B Ab in body fluid - centromere protein B Ab in CSF - centromere protein B Ab in serum - centromere protein B IgG in serum

Related

anti-centromere protein B antibody CENP B gene

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 599 aa MW = 65 kD COMPARTMENT: cell nucleus MOTIF: HTH psq-type {1-52} MOTIF: DNA-binding motif SITE: 28-48 HTH CENPB-type {65-136} MOTIF: DNA-binding motif SITE: 97-129 Ser phosphorylation site {S156} Ser phosphorylation site {S165} glutamate-rich region {404-465} MOTIF: glutamate residue (SEVERAL) acidic region {508-538} MOTIF: acidic residue (SEVERAL)

Database Correlations

OMIM 117140 UniProt P07199 PFAM correlations Entrez Gene 1059 Kegg hsa:1059

References

  1. UniProt :accession P07199
  2. Ross CA, McInnis MG, Margolis RL, Li SH. Genes with triplet repeats: candidate mediators of neuropsychiatric disorders. Trends Neurosci. 1993 Jul;16(7):254-60. Review. PMID: 7689767
  3. Medical Knowledge Self Assessment Program (MKSAP) 18, American College of Physicians, Philadelphia 2018