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CENPA-NAC (nucleosome-associated) complex
Function:
1) nucleosome-associated complex
2) assembly of kinetochore proteins
3) mitotic progression
4) chromosome segregation
5) recruits CENPA-CAD complex (nucleosome distal)
6) incorporation of newly synthesized CENPA into centromeres
Structure:
- consists of:
- CENPA, CENPC, CENPH, CENPM, CENPN, CENPT, MLF1IP/CENPU
General
molecular complex
Properties
SUBUNITS: histone H3-like centromeric protein A
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S7}
Ser phosphorylation site {S17}
Ser phosphorylation site {S19}
Thr phosphorylation site {T23}
Ser phosphorylation site {S27}
H3-like {41-140}
MOTIF: CATD {75-116}
centromere protein C 1
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T167}
Ser phosphorylation site {S170}
Ser phosphorylation site {S177}
Ser phosphorylation site {S225}
peptide motif {259-273}
MOTIF: Ser phosphorylation site {S261}
Ser phosphorylation site {S316}
Ser phosphorylation site {S333}
peptide motif {484-499}
Ser phosphorylation site {S520}
Ser phosphorylation site {S524}
Ser phosphorylation site {S538}
peptide motif {558-574}
Ser phosphorylation site {S763}
Ser phosphorylation site {S773}
peptide motif {780-798}
centromere protein H
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
coiled coil {47-192}
proliferation-associated nuclear element protein 1
COMPARTMENT: cytoplasm
cell nucleus
centromere protein N
COMPARTMENT: cell nucleus
centromere protein T
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S188}
centromere protein U
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: nuclear translocation signal {6-23}
Ser phosphorylation site {S94}
Ser phosphorylation site {S229}
coiled coil {297-356}
MOTIF: nuclear translocation signal {303-320}
coiled coil {397-417}
References
UniProt :accession Q99743
Components
centromere protein C 1; CENP-C; centromere autoantigen C; interphase centromere complex protein 7 (CENPC1 CENPC ICEN7)
centromere protein H; CENP-H; interphase centromere complex protein 35; centromere autoantigen H (CENPH, ICEN35)
centromere protein N (CENP-N, interphase centromere complex protein 32, CENPN, C16orf60, ICEN32, BM-309)
centromere protein T (CENP-T, interphase centromere complex protein 22, CENPT, C16orf56, ICEN22)
centromere protein U (CENP-U, CENP-U50, CENP-50, interphase centromere complex protein 24, MLF1-interacting protein, KSHV latent nuclear antigen-interacting protein 1, MLF1IP, CENPU, ICEN24, KLIP1)
histone H3-like centromeric protein A; centromere protein A; centromere autoantigen A; CENP-A (CENPA)
proliferation-associated nuclear element protein 1: centromere protein M; CENP-M; interphase centromere complex protein 39 (CENPM, C22orf18, ICEN39, PANE1)