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cell surface glycoprotein MUC18; melanoma-associated antigen MUC18; melanoma cell adhesion molecule; melanoma-associated antigen A32; S-endo 1 endothelial-associated antigen; cell surface glycoprotein P1H12; CD146 (MCAM, MUC18)
Function:
- plays a role in cell adhesion, & in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue
- expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread
- could be an adhesion molecule active in neural crest cells during embryonic development
- acts as surface receptor that triggers Tyr phosphorylation of FYN & PTK2, & a transient increase in the intracellular Ca+2
Structure:
- contains 3 Ig-like C2-type domains (immunoglobulin-like)
- contains 2 Ig-like V-type domains (immunoglobulin-like)
Compartment:
- membrane; single-pass type 1 membrane protein
Alternative splicing: named isoforms=2
Expression:
- detected in endothelial cells in vascular tissue throughout the body
- may appear at the surface of neural crest cells during their embryonic migration
- appears to be limited to vascular smooth muscle in normal adult tissues
Pathology:
- associated with tumor progression & the development of metastasis in human malignant melanoma
- expressed most strongly on metastatic lesions & advanced primary tumors
- only rarely detected in benign melanocytic nevi & thin primary melanomas with a low probability of metastasis
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
immunoglobulin superfamily protein
melanoma associated antigen (MAGE)
phosphoprotein
Properties
SIZE: entity length = 646 aa
MW = 72 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
immunoglobulin superfamily domain {24-129}
MOTIF: cysteine residue {C48}
MODIFICATION: cysteine residue {C116}
N-glycosylation site {N56}
cysteine residue {C116}
MODIFICATION: cysteine residue {C48}
immunoglobulin superfamily domain {139-242}
MOTIF: cysteine residue {C161}
MODIFICATION: cysteine residue {C223}
cysteine residue {C223}
MODIFICATION: cysteine residue {C161}
immunoglobulin superfamily domain {244-330}
MOTIF: cysteine residue {C272}
MODIFICATION: cysteine residue {C320}
cysteine residue {C320}
MODIFICATION: cysteine residue {C272}
immunoglobulin superfamily domain {335-424}
MOTIF: cysteine residue {C365}
MODIFICATION: cysteine residue {C407}
cysteine residue {C407}
MODIFICATION: cysteine residue {C365}
N-glycosylation site {N418}
immunoglobulin superfamily domain {430-510}
MOTIF: N-glycosylation site {N449}
cysteine residue {C452}
MODIFICATION: cysteine residue {C499}
N-glycosylation site {N467}
cysteine residue {C499}
MODIFICATION: cysteine residue {C452}
N-glycosylation site {N508}
N-glycosylation site {N518}
N-glycosylation site {N527}
N-glycosylation site {N544}
transmembrane domain {560-583}
Ser phosphorylation site {S606}
Ser phosphorylation site {S614}
Database Correlations
OMIM 155735
UniProt P43121
PFAM correlations
Entrez Gene 4162
Kegg hsa:4162
References
UniProt :accession P43121