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tetraspanin-7; Tspan-7; transmembrane 4 superfamily member 2; cell surface glycoprotein A15; T-cell acute lymphoblastic leukemia-associated antigen 1; TALLA-1; membrane component, X chromosome, surface marker 1; CD231 (TSPAN7, A15, DXS1692E, MXS1, TM4SF2)
Function:
- may be involved in cell proliferation & cell motility
Structure: belongs to the tetraspanin (TM4SF) family
Compartment: membrane
Expression:
- not solely expressed in T-cells
- expressed in acute myelocytic leukemia cells of some patients
Pathology:
- defects in TSPAN7 are the cause of X-linked mental retardation 58 (MRX58)
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
tetraspanin (transmembrane-4-superprotein)
Properties
SIZE: entity length = 249 aa
MW = 28 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-16}
transmembrane domain {17-40}
exoplasmic loop {41-56}
MOTIF: N-glycosylation site {N54}
transmembrane domain {57-75}
cytoplasmic loop {76-86}
transmembrane domain {87-112}
exoplasmic loop {113-213}
MOTIF: N-glycosylation site {N155}
N-glycosylation site {N158}
N-glycosylation site {N177}
N-glycosylation site {N188}
transmembrane domain {214-234}
cytoplasmic domain {235-249}
Database Correlations
OMIM correlations
MORBIDMAP 300096
UniProt P41732
Pfam PF00335
Entrez Gene 7102
Kegg hsa:7102
References
- UniProt :accession P41732
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/TSPAN7