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cell surface A33 antigen (glycoprotein A33, GPA33)
Function:
- role in cell-cell recognition & signaling
Structure:
- N-glycosylated, contains approximately 8 kD of N-linked carbohydrate
- palmitoylated
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: membrane
Expression:
- expressed in normal gastrointestinal epithelium
Pathology:
- expressed in 95% of colon cancers (but also expressed in normal gastrointestinal epithelium)
Related
V-set & immunoglobulin domain-containing protein 1; cell surface A33 antigen; glycoprotein A34 (VSIG1, GPA34)
General
glycoprotein
membrane protein
Properties
SIZE: MW = 36 kD
entity length = 319 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {22-134}
MOTIF: cysteine residue {C43}
MODIFICATION: cysteine residue {C117}
N-glycosylation site {N112}
cysteine residue {C117}
MODIFICATION: cysteine residue {C43}
immunoglobulin superfamily domain {140-227}
MOTIF: cysteine residue {C146}
MODIFICATION: cysteine residue {C222}
cysteine residue {C162}
MODIFICATION: cysteine residue {C211}
N-glycosylation site {N200}
cysteine residue {C211}
MODIFICATION: cysteine residue {C162}
cysteine residue {C222}
MODIFICATION: cysteine residue {C146}
N-glycosylation site {N223}
transmembrane domain {236-256}
Database Correlations
OMIM 602171
UniProt Q99795
PFAM correlations
References
UniProt :accession Q99795