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cell growth regulator with EF hand domain protein 1; cell growth regulatory gene 11 protein; hydrophobestin (CGREF1, CGR11)
Function:
- inhibits cell growth of several cell lines
- mediates cell-cell adhesion (Ca+2-dependent)
- probably metabolized extracellularly by an unknown serine protease generating extremely hydrophobic bioactive peptides
Structure:
- contains 2 EF-hand domains
- both EF-hands are required for function (putative)
Compartment: secreted (putative)
Expression: induced by p53
General
Ca+2 binding protein
secreted protein
Properties
SIZE: entity length = 301 aa
MW = 32 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
EF hand
SITE: 69-104
MOTIF: Ca+2-binding site
SITE: 82-93
EF hand
SITE: 114-149
MOTIF: Ca+2-binding site
SITE: 127-138
Database Correlations
OMIM 606137
UniProt Q99674
Entrez Gene 10669
Kegg hsa:10669
References
UniProt :accession Q99674