cell division cycle-associated protein 7 (protein JPO1) (CDCA7 JPO1)

Function: - role in MYC-mediated cell transformation - induces anchorage-independent growth & clonogenicity in lymphoblastoid cells - insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis - role as transcriptional regulator - activated by MYC & possibly E2F1 Compartment: nucleus Alternative splicing: named isoforms=4 Expression: - ubiquitous with higher level in thymus & small intestine Pathology: - expression correlated with MYC expression in lymphoblastoid, lymphoma & breast cancer cell lines - overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) & in chronic myelogenous leukemia (CML) blast crisis

General

cell division cycle-associated protein 4 (CDCA) transcription factor (TF)

Properties

SIZE: MW = 43 kD entity length = 371 aa COMPARTMENT: cell nucleus MOTIF: arginine-rich region {157-186} MOTIF: arginine residue (SEVERAL) transcriptional activity {247-371}

References

UniProt :accession Q9BWT1