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cell division cycle-associated protein 3 (trigger of mitotic entry protein 1, TOME-1, gene-rich cluster protein C8, CDCA3, C8, GRCC8, TOME1)
Function:
- F-box-like protein, required for entry into mitosis
- component of SCF complex
- interacts with E3 ligase complexes that mediate ubiquitination & degradation of WEE1 kinase at G2/M phase
- role in ubiquitin conjugation 3rd step
- interacts with SKP1A
- ubiquitinated & degraded by APC/C-Cdh1 complex
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- KEN box is required for the association with APC/C-Cdh1 complex
Compartment: cytoplasm
General
cell division cycle-associated protein 4 (CDCA)
phosphoprotein
Properties
SIZE: MW = 29 kD
entity length = 268 aa
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S68}
F-box-like {91-120}
Thr phosphorylation site {T159}
Ser phosphorylation site {S165}
Thr phosphorylation site {T177}
Ser phosphorylation site {S199}
Ser phosphorylation site {S209}
KEN box {258-260}
Database Correlations
OMIM 607749
UniProt Q99618
References
UniProt :accession Q99618