cell division cycle-associated 7-like protein (protein JPO2, transcription factor RAM2, CDCA7L, HR1, JPO2 R1)

Function: - role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity & gene expression by binding to the promoter - role in apoptotic signaling pathways - may act downstream of P38-kinase & BCL-2, but upstream of CASP3/caspase-3, CCND1/cyclin D1 & E2F1 - interacts with MYC & PSIP1 Compartment: - cytoplasm, nucleus - associates with chromatin - translocates from cytoplasm to nucleus under dexamethasone induction Alternative splicing: named isoforms=2 Expression: ubiquitous Pathology: - overexpressed in medulloblastoma - role in mediating the full transforming effect of MYC in medulloblastoma cells - induced by MYC overexpression in neuroblastoma cell line

General

cell division cycle-associated protein 4 (CDCA) phosphoprotein transcriptional silencer (transcriptional repressor)

Properties

SIZE: MW = 52 kD entity length = 454 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: Ser phosphorylation site {S21} binding site SITE: 58-119 FOR-BINDING-OF: PC4 & SFRS1-interacting protein MOTIF: Thr phosphorylation site {T77} Ser phosphorylation site {S79} Ser phosphorylation site {S105} Ser phosphorylation site {S108} Ser phosphorylation site {S114} Ser phosphorylation site {S117} binding site SITE: 213-235 FOR-BINDING-OF: myc protein family

References

UniProt :accession Q96GN5