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cell division cycle 7-related protein kinase; CDC7-related kinase; HsCdc7; huCdc7 (CDC7, CDC7L1)
Function:
- seems to phosphorylate critical substrates that regulate the G1/S phase transition &/or DNA replication
- phosphorylates MCM2 & MCM3
- may phosphorylate p34RPA
- forms a complex with either DBF4/DBF4A or DBF4B, leading to activation of the kinase activity
Cofactor: Mg+2
Structure:
- belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CDC7 subfamily
- contains 1 protein kinase domain
Compartment: nucleus
Alternative splicing:
- named isoforms=1
- a number of isoforms may be produced
Comparative biology:
- yeast CDC7 is required in vivo for mutagenic repair in Saccharomyces cerevisiae following exposure to DNA-damaging agents
General
nuclear protein
serine/threonine kinase
Properties
SIZE: entity length = 574 aa
MW = 64 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S16}
Ser phosphorylation site {S27}
kinase domain
SITE: 58-574
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 64-72
ATP-binding site
NAME: ATP-binding site
SITE: 90-90
aspartate residue {D177}
Thr phosphorylation site {T503}
Tyr phosphorylation site {Y508}
Ser phosphorylation site {S509}
STATE: active state
Database Correlations
OMIM 603311
UniProt O00311
Pfam PF00069
Entrez Gene 8317
Kegg hsa:8317
ENZYME 2.7.11.1
References
- UniProt :accession O00311
- NIEHS-SNPs
http://egp.gs.washington.edu/data/cdc7/