Search
cyclin-dependent kinase-12 (CDK12); Cdc2-related kinase, arginine/serine-rich; CrkRS; cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; cell division protein kinase 12; hCDK12 (CRK7, CRKRS, KIAA0904)
Function:
- cyclin-dependent kinase
- displays CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thus acting as a regulator of transcription elongation.
- required for RNA splicing, possibly by phosphorylating SRSF1/SF2
- role in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors
- interacts with CCNL1 & CCNL2 (putative)
Structure:
- belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
- contains 1 protein kinase domain
Compartment:
- nucleus. nuclear speckle
- colocalized with nuclear speckles throughout interphase
Alternative splicing: named isoforms=3
Expression: ubiquitously expressed
Pathology:
- chromosomal deletion within 17q12 region involving CDK12 producing fusion transcripts with ERBB2 may be a cause of gastric cancer
- deletion leads to CDK12-ERBB2 fusion with truncated CDK12 protein not in-frame with ERBB2
General
cyclin-dependent kinase (CDK)
nuclear protein
Properties
SIZE: entity length = 1490 aa
MW = 164 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S14}
Ser phosphorylation site {S24}
Ser phosphorylation site {S25}
Ser phosphorylation site {S29}
Ser phosphorylation site {S32}
Thr phosphorylation site {T57}
Ser phosphorylation site {S62}
Tyr phosphorylation site {Y73}
Ser phosphorylation site {S77}
Ser phosphorylation site {S78}
Ser phosphorylation site {S80}
Thr phosphorylation site {T82}
Ser phosphorylation site {S84}
Ser phosphorylation site {S215}
Ser phosphorylation site {S228}
Ser phosphorylation site {S236}
Ser phosphorylation site {S238}
Ser phosphorylation site {S249}
Ser phosphorylation site {S265}
Ser phosphorylation site {S274}
Ser phosphorylation site {S276}
Tyr phosphorylation site {Y279}
Ser phosphorylation site {S291}
Ser phosphorylation site {S293}
Ser phosphorylation site {S301}
Ser phosphorylation site {S303}
Ser phosphorylation site {S318}
Tyr phosphorylation site {Y319}
Ser phosphorylation site {S320}
Ser phosphorylation site {S323}
Ser phosphorylation site {S325}
Ser phosphorylation site {S332}
Ser phosphorylation site {S333}
Ser phosphorylation site {S334}
Ser phosphorylation site {S341}
Ser phosphorylation site {S343}
Ser phosphorylation site {S345}
Ser phosphorylation site {S382}
Ser phosphorylation site {S383}
Ser phosphorylation site {S385}
Ser phosphorylation site {S393}
Ser phosphorylation site {S400}
alanine-rich region {407-413}
MOTIF: alanine residue (SEVERAL)
Ser phosphorylation site {S420}
Ser phosphorylation site {S423}
Ser phosphorylation site {S434}
Thr phosphorylation site {T514}
proline-rich region
SITE: 535-540
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S681}
Ser phosphorylation site {S685}
Thr phosphorylation site {T692}
kinase domain
SITE: 727-1020
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 733-741
ATP-binding site
NAME: ATP-binding site
SITE: 756-756
aspartate residue {D859}
Tyr phosphorylation site {Y892}
Thr phosphorylation site {T893}
Ser phosphorylation site {S1053}
Thr phosphorylation site {T1070}
Thr phosphorylation site {T1074}
Thr phosphorylation site {T1076}
Ser phosphorylation site {S1082}
Ser phosphorylation site {S1083}
Thr phosphorylation site {T1244}
proline-rich region
SITE: 1266-1280
MOTIF: proline residue (SEVERAL)
STATE: active state
Database Correlations
UniProt Q9NYV4
Pfam PF00069
Entrez Gene 51755
Kegg hsa:51755
ENZYME correlations
References
UniProt :accession Q9NYV4