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cell division control protein 6 homolog; CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6 (CDC6, CDC18L)
Function:
- role in the initiation of DNA replication
- also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated
- interacts with PCNA, ORC1L, cyclin-CDK & HUWE1
Structure: belongs to the CDC6/cdc18 family
Compartment:
- nucleus. cytoplasm
- nuclear in G1 & cytoplasmic in S-phase cells
Pathology:
- defects in CDC6 are the cause of Meier-Gorlin syndrome type 5
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 560 aa
MW = 63 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S45}
Ser phosphorylation site {S54}
Thr phosphorylation site {T166}
ATP-binding site
NAME: ATP-binding site
SITE: 202-209
Database Correlations
OMIM correlations
UniProt Q99741
Pfam PF09079
Entrez Gene 990
Kegg hsa:990
References
- UniProt :accession Q99741
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/CDC6ID40014ch17q21.html
- NIEHS-SNPs
http://egp.gs.washington.edu/data/cdc6/
Component-of
pre-replication complex