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cell cycle checkpoint protein RAD1; hRAD1; DNA repair exonuclease rad1 homolog; Rad1-like DNA damage checkpoint protein (RAD1, REC1)
Function:
1) component of the 9-1-1 complex
2) isoform 1 possesses 3'->5' double stranded DNA exonuclease activity to yield nucleoside 5'-phosphates
3) RAD1 interacts with POLB, FEN1, HUS1, HUS1B, RAD9A, RAD9B
4) interacts with DNAJC7
Structure: belongs to the rad1 family
Compartment: nucleus
Alternative splicing:
- named isoforms=3
- at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Expression:
- expressed in testis, uterus, bladder, spleen, ovaries, lung, brain, muscle
General
exodeoxyribonuclease
nuclear protein
Properties
SIZE: entity length = 282 aa
MW = 32 kD
COMPARTMENT: cell nucleus
MOTIF: active site
Database Correlations
OMIM 603153
UniProt O60671
Pfam PF02144
Entrez Gene 5810
Kegg hsa:5810
References
- UniProt :accession O60671
- NIEHS-SNPs
http://egp.gs.washington.edu/data/rad1/
Component-of
9-1-1 cell-cycle checkpoint response complex