cell cycle & apoptosis regulator protein 2; cell division cycle & apoptosis regulator protein 2; DBIRD complex subunit KIAA1967; deleted in breast cancer gene 1 protein; DBC-1; DBC.1; p30 DBC (CCAR2, DBC1, KIAA1967)

Function: - core component of the DBIRD complex - inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation & p53-mediated apoptosis - inhibits SUV39H1 methyltransferase activity - component of a histone H3-specific methyltransferase complex - may mediate ligand-dependent transcriptional activation by nuclear hormone receptors - role in maintaining genomic stability & cellular integrity following UV-induced genotoxic stress - interacts with ZNF326/ZIRD (direct) - interacts (via N-terminus) with SIRT1 - interacts (via N-terminus) with SUV39H1 - interaction abolishes the interaction with SIRT1 Compartment: - nucleus - recruited to chromatin, post- UV irradiation Alternative splicing: named isoforms=2 Expression: - expressed ubiquitously in normal tissues Pathology: - expressed in 84-100% of breast cancer, lung cancer, colon cancer

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 923 aa MW = 103 kD COMPARTMENT: cell nucleus MOTIF: Thr phosphorylation site {T35} Ser phosphorylation site {S124} Ser phosphorylation site {S675} Ser phosphorylation site {S678} Ser phosphorylation site {S681} coiled coil {829-909}

Database Correlations

OMIM 607359 UniProt Q8N163

References

UniProt :accession Q8N163