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cell adhesion molecule-related/down-regulated by oncogenes (CDON, CDO)
Function:
1) component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells
2) promotes differentiation of myogenic cells
3) component of complex containing BOC, CDON, NEO1, cadherins, CTNNB1
4) interacts with NTN3
5) interacts with GAS1
Structure:
- N-glycosylated
- contains 3 fibronectin F3 domains
- contains 5 Ig-like C2-type domains
Compartment: membrane
Alternative splicing: named isoforms=2
Pathology:
- defects in CDON are the cause of holoprosencephaly type 11
General
adhesion receptor
glycoprotein
Properties
SIZE: MW = 139 kD
entity length = 1287 aa
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-25}
immunoglobulin superfamily domain {29-114}
MOTIF: cysteine residue {C50}
MODIFICATION: cysteine residue {C97}
N-glycosylation site {N88}
cysteine residue {C97}
MODIFICATION: cysteine residue {C50}
N-glycosylation site {N100}
immunoglobulin superfamily domain {120-204}
MOTIF: cysteine residue {C141}
MODIFICATION: cysteine residue {C191}
N-glycosylation site {N180}
cysteine residue {C191}
MODIFICATION: cysteine residue {C141}
immunoglobulin superfamily domain {225-303}
MOTIF: cysteine residue {C243}
MODIFICATION: cysteine residue {C290}
N-glycosylation site {N287}
cysteine residue {C290}
MODIFICATION: cysteine residue {C243}
N-glycosylation site {N294}
immunoglobulin superfamily domain {310-396}
MOTIF: cysteine residue {C333}
MODIFICATION: cysteine residue {C380}
N-glycosylation site {N342}
cysteine residue {C380}
MODIFICATION: cysteine residue {C333}
immunoglobulin superfamily domain {405-516}
MOTIF: cysteine residue {C426}
MODIFICATION: cysteine residue {C500}
N-glycosylation site {N427}
cysteine residue {C500}
MODIFICATION: cysteine residue {C426}
N-glycosylation site {N570}
fibronectin type III domain or F3 module {577-673}
fibronectin type III domain or F3 module {721-813}
fibronectin type III domain or F3 module {826-923}
MOTIF: N-glycosylation site {N873}
transmembrane domain {964-984}
Database Correlations
OMIM correlations
UniProt Q4KMG0
PFAM correlations
Entrez Gene 50937
Kegg hsa:50937
References
UniProt :accession Q4KMG0