Search
cell adhesion molecule 4 (immunoglobulin superfamily member 4C, nectin-like protein 4, TSLC1-like protein 2, CADM4, IGSF4C, NECL4, TSLL2)
Function:
- role in cell-cell adhesion
- Ca+2-& Mg+2-independent cell-cell adhesion activity
- may have tumor-suppressor activity
Structure:
- monomer & homodimer
- N-glycosylated
- belongs to the nectin family
- contains 2 Ig-like C2-type domains (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: membrane
Expression:
- expressed in brain, prostate, brain, kidney & some other organs
General
adhesion receptor
glycoprotein
immunoglobulin superfamily protein
Properties
SIZE: MW = 43 kD
entity length = 388 aa
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-20}
immunoglobulin superfamily domain {21-119}
MOTIF: N-glycosylation site {N31}
cysteine residue {C44}
MODIFICATION: cysteine residue {C104}
N-glycosylation site {N67}
cysteine residue {C104}
MODIFICATION: cysteine residue {C44}
immunoglobulin superfamily domain {124-219}
MOTIF: cysteine residue {C145}
MODIFICATION: cysteine residue {C199}
cysteine residue {C199}
MODIFICATION: cysteine residue {C145}
immunoglobulin superfamily domain {224-307}
MOTIF: cysteine residue {C245}
MODIFICATION: cysteine residue {C291}
N-glycosylation site {N286}
cysteine residue {C291}
MODIFICATION: cysteine residue {C245}
transmembrane domain {325-345}
Database Correlations
UniProt Q8NFZ8
PFAM correlations
References
UniProt :accession Q8NFZ8