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cell adhesion molecule 1; immunoglobulin superfamily member 4; nectin-like protein 2; NECL-2; tumor suppressor in lung cancer 1; TSLC-1; synaptic cell adhesion molecule; spermatogenic immunoglobulin superfamily; SgIGSF (CADM1, IGSF4, NECL2, SYNCAM, TSLC1)

Function: - mediates homophilic cell-cell adhesion (Ca+2-independent) - also mediates heterophilic cell-cell adhesion with CADM3 & PVRL3 (Ca+2-independent) - acts as tumor suppressor in non-small-cell lung cancer cells - interaction with CRTAM promotes - NK cell cytotoxicity & IFN-gamma secretion by CD8+ cells in vitro - NK cell-mediated rejection of tumors expressing CADM3 in vivo - may contribute to the less invasive phenotypes of lepidic growth tumor cells - in mast cells, may mediate attachment to & promote communication with nerves - CADM1, together with MITF, is essential for development & survival of mast cells in vivo - synaptic cell adhesion molecule that plays a role in formation of dendritic spines & drives synapse assembly - role in neuronal migration, axon growth, pathfinding, & fasciculation on the axons of differentiating neurons - glycosylation at Asn-67 & Asn-101 promotes adhesive binding & synapse induction - diverse roles in spermatogenesis including - adhesion of spermatocytes & spermatids to Sertoli cells - normal differentiation into mature spermatozoa - interacts with CRTAM - interacts with EPB41L3/DAL1 via C-terminus - interaction with EPB41L3/DAL1 may act to anchor CADM1 to actin cytoskeleton - interacts via its C-terminus with the PDZ domain of MPP3 & the PDZ domain of MPP6. Structure: - homodimer - cytoplasmic domain appears to play a critical role in proapoptosis & tumor suppressor activity in NSCLC - belongs to the nectin family - contains 2 Ig-like C2-type domains (immunoglobulin-like) - contains 1 Ig-like V-type domains (immunoglobulin-like) Compartment: - cell membrane - cell junction, synapse - associates with perinuclear & plasma membranes in vivo - localized to the basolateral plasma membrane of epithelial cells in gall bladder Alternative splicing: named isoforms=5 Pathology: 1) absent or down-regulated in many advanced cases of NSCLC as well as in many other human cancers, due to gene silencing by promoter methylation 2) may contribute to less invasive phenotypes of lepidic growth tumor cells

General

anti-oncoprotein (tumor suppressor protein) glycoprotein human longevity protein immunoglobulin superfamily protein membrane protein

Properties

SIZE: MW = 49 kD entity length = 442 aa COMPARTMENT: cell nucleus MOTIF: signal sequence {1-44} immunoglobulin superfamily domain {45-139} MOTIF: cysteine residue {C64} MODIFICATION: cysteine residue {C124} N-glycosylation site {N101} N-glycosylation site {N113} cysteine residue {C124} MODIFICATION: cysteine residue {C64} immunoglobulin superfamily domain {144-238} MOTIF: N-glycosylation site {N165} cysteine residue {C166} MODIFICATION: cysteine residue {C220} cysteine residue {C220} MODIFICATION: cysteine residue {C166} immunoglobulin superfamily domain {243-329} MOTIF: cysteine residue {C267} MODIFICATION: cysteine residue {C313} N-glycosylation site {N308} cysteine residue {C313} MODIFICATION: cysteine residue {C267} transmembrane domain {375-395}

Database Correlations

OMIM 605686 UniProt Q9BY67 PFAM correlations Entrez Gene 23705 Kegg hsa:23705

References

  1. UniProt :accession Q9BY67
  2. UniProt PubMed links - PMID: 11279526 - PMID: 279526 - PMID: 12234973 - PMID: 234973 - PMID: 15811952 - PMID: 811952 - PMID: 22438059 - PMID: 12050160 - PMID: 050160 - PMID: 13679854 - PMID: 679854