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cellulose/citric acid (Plenity)

1) Indications: - weight reduction Dosage: - oral hydrogel capsule taken with water before lunch and dinner. Mechanism of action: - oral hydrogel capsule, made of cellulose & citric acid - in the stomach, the capsules release particles that absorb water - gel particles help patients feel full by boosting the volume & elasticity of the contents in the stomach & small intestine * 59% of patients lost >= 5% of their weight within 6 months [1]

General

pharmacologic combination

References

  1. Greenwau FL, Aronne LJ,Raben A et al A Randomized, Double-Blind, Placebo-Controlled Study of Gelesis100: A Novel Nonsystemic Oral Hydrogel for Weight Loss. Obesity (Silver Spring). 2019 Feb;27(2):205-216. Online: Nov 13, 2018 PMID: 30421844 https://onlinelibrary.wiley.com/doi/10.1002/oby.22347
  2. Gelesis Granted FDA Clearance to Market PLENITY - a New Prescription Aid in Weight Management. BOSTON, April 14, 2019 (Gelesis) https://www.gelesis.com/2019/04/14/gelesis-granted-fda-clearance-to-market-plenitytm-a-new-prescription-aid-to-weight-management/
  3. Instructions for UseProduct: Plenity https://www.gelesis.com/wp-content/uploads/DEN180060_Physician_IFU_FDA_FINAL_4.9.2019Gelesis.pdf

Components

cellulose (Calcibind) citrate (citric acid)