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CECR2-containing-remodeling factor (CERF) complex

Function: - facilitates perturbation of chromatin structure (ATP-dependent) manner - role in integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling & cytokinesis via interaction with LRPPRC Componenets: CECR2 & SMARCA1

General

molecular complex

Properties

SUBUNITS: cat eye syndrome critical region protein 2 MOTIF: glutamate-rich region {333-337} MOTIF: glutamate residue (SEVERAL) bromodomain {451-521} serine-rich region {611-614} MOTIF: serine residue (SEVERAL) proline-rich region SITE: 1250-1253 MOTIF: proline residue (SEVERAL) transcription activator SNF2L COMPARTMENT: cell nucleus MOTIF: helicase NAME: helicase SITE: 195-360 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 208-215 DEAD/H box NAME: DEAD/H box SITE: 311-314 Helicase C-terminal {490-653} Ser phosphorylation site {S725} SANT 1 {855-907} Tyr phosphorylation site {Y954} SANT 2 {958-1022}

References

UniProt :accession Q9BXF3

Components

cat eye syndrome critical region protein 2 (CECR2, KIAA1740) global transcription activator SNF2L1; nucleosome-remodeling factor subunit SNF2L; ATP-dependent helicase SMARCA1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1, SNF2L, SNF2L1)