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cyclin-dependent kinase inhibitor 3; CDK2-associated dual-specificity phosphatase; kinase-associated phosphatase; cyclin-dependent kinase-interacting protein 2; cyclin-dependent kinase interactor 1 (CDKN3, CDI1, CIP2, KAP)
Function:
- may play a role in cell cycle regulation
- dual specificity phosphatase active toward substrates containing either phospho-Tyr or phospho-Ser
- dephosphorylates CDK2 at Thr-160 (cyclin-dependent)
- interacts with cyclin-dependent kinases CDC2, CDK2 & CDK3 but not CDK4
- interacts (via C-terminus) with phosphorylated CDK2 (via C-terminal helix)
- interacts with MS4A3 (via C-terminus); the interaction enhances CDKN3 enzymatic activity
Structure:
- belongs to the protein-tyrosine phosphatase family
Compartment: cytoplasm, perinuclear region
Alternative splicing: named isoforms=2
Expression:
- expressed at G1->S transition in HeLa cells
Pathology:
- defects in CDKN3 are found in patients with hepatocellular carcinoma
- up-regulated in breast cancer & prostate cancer cells
Related
cell cycle
General
cyclin-dependent kinase inhibitor (CDKI, CDKN)
dual specificity phosphatase
nuclear protein
Properties
COMPARTMENT: cytoplasm
cell nucleus
INHIBITS: protein kinase
SIZE: entity length = 212 aa
MW = 24 kD
STATE: active state
MOTIF: CDK2 interaction {1-34}
active site
MOTIF: HC motif
cysteine residue {C140}
Database Correlations
OMIM correlations
UniProt Q16667
Pfam PF05706
Entrez Gene 1033
ENZYME correlations
References
- OMIM :accession 123832
- Gyuris J et al
Cdi1, a human G1 and S phase protein phosphatase that
associates with Cdk2.
Cell 75:791-803,1993
PMID: 8242750
- Entrez Gene :accession 1033
- UniProt :accession Q16667
- NIEHS-SNPs
http://egp.gs.washington.edu/data/cdkn3/