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cyclin-dependent kinase 4 inhibitor D; CDK inhibitor-2D; p19-INK4d (CDKN2D)
Function:
- interacts with CDK4 & CDK6 & inhibits them [1,4]
Structure:
- belongs to the CDKN2 cyclin-dependent kinase inhibitor family
- contains 4 ANK repeats
General
cyclin-dependent kinase inhibitor (CDKI, CDKN)
nuclear protein
Properties
COMPARTMENT: cell nucleus
INHIBITS: protein kinase
SIZE: entity length = 166 aa
MW = 18 kD
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
ankyrin repeat
NAME: ankyrin repeat
SITE: 41-69
ankyrin repeat
NAME: ankyrin repeat
SITE: 73-102
ankyrin repeat
NAME: ankyrin repeat
SITE: 106-135
ankyrin repeat
NAME: ankyrin repeat
SITE: 138-166
Database Correlations
OMIM 600927
UniProt P55273
Pfam PF00023
Entrez Gene 1032
Kegg hsa:1032
References
- Cordon-Cardo C.
Mutations of cell cycle regulators. Biological and clinical
implications for human neoplasia.
Am J Pathol. 1995 Sep;147(3):545-60. Review.
PMID: 7677168
- OMIM :accession 600927
- Entrez Gene :accession 1032
- UniProt :accession P55273
- NIEHS-SNPs
http://egp.gs.washington.edu/data/cdkn2d/