CDKN2A-interacting protein (collaborator of ARF, CDKN2AIP, CARF)

Function: - activates TP53/p53 by CDKN2A-dependent & CDKN2A-independent pathways - interacts with CDKN2A/p14ARF, TP53/p53 & MDM2 - may be ubiquitinated Structure: - belongs to the CARF family - contains 1 DRBM (double-stranded RNA-binding) domain Compartment: nucleus, nucleoplasm Expression: ubiquitously expressed

General

nuclear protein phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 579 aa MW = 61 kD COMPARTMENT: cell nucleus MOTIF: serine-rich region {175-424} MOTIF: serine residue (SEVERAL) Thr phosphorylation site {T345} DRBM {461-536}

Database Correlations

UniProt Q9NXV6 Kegg hsa:5560

References

UniProt :accession Q9NXV6