CDK5 & ABL1 enzyme substrate 1; interactor with CDK3 1; Ik3-1 (CABLES1 CABLES)

Function: 1) cyclin-dependent kinase binding protein 2) enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases a) phosphorylation of CDK5 by activated ABL1 - increases CDK5 activity - involved in neuronal development b) phosphorylation of CDK2 by WEE1 - decreased CDK2 activity - growth inhibition 3) positively affects neuronal outgrowth 4) regulates p53/p73-induced cell death (putative) 5) component of several complexes a) complex with p53 b) complexes with CDK2, CDK3, CDK5, ABL1, TDRD7, PCTK2, CCNA1, CCNE1, TP73 6) interacts with CDK2, CDK3, CDK5, ABL1, TDRD7 7) phosphorylated on Ser-313 by CCNE1 8) phosphorylated on Ser/Thr by CDK5 & on Tyr by ABL1 9) phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 & CCNE1/CDK3 Structure: belongs to the cyclin family Compartment: - nucleus, cytoplasm - located in cell body & proximal region of the developing axonal shaft of immature neurons - located in axonal growth cone of mature neurons Alternative splicing: named isoforms=3 Expression: - expressed in breast, pancreas, colon, head & neck (at protein level) - expression in endometrial epithelium fluctuates during menstrual cycle, greater in secretory phase than proliferative phase - up-regulated by progesterone - down-regulated by estrogen Pathology: - decreased expression in > 90% of endometrial cancers

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 633 aa MW = 68 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: TDRD7 interaction {1-109} alanine-rich region {2-134} MOTIF: alanine residue (SEVERAL) Ser phosphorylation site {S168} CDK3 interaction {179-492} MOTIF: Ser phosphorylation site {S242} Ser phosphorylation site {S287} Ser phosphorylation site {S290} Ser phosphorylation site {S291} Thr phosphorylation site {T294} Ser phosphorylation site {S311} Ser phosphorylation site {S313} Ser phosphorylation site {S373} Thr phosphorylation site {T415} Ser phosphorylation site {S418} Thr phosphorylation site {T419} Ser phosphorylation site {S421} Ser phosphorylation site {S434} Ser phosphorylation site {S439}

Database Correlations

OMIM 609194 UniProt Q8TDN4 Pfam PF00134 Entrez Gene 91768 Kegg hsa:91768

References

UniProt :accession Q8TDN4