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CDK1/cyclin-A complex

Activity may depend upon T167 phosphorylation of p34cdc2, complexing of p34cdc2 to cyclin A, & Y15 & T14 dephosphorylation of p34cdc2.

Interactions

molecular events

General

CDK/cyclin complex serine/threonine kinase

Properties

COMPARTMENT: cell nucleus CELL-CYCLE: G1/S STATE: active state SUBUNITS: cyclin-dependent kinase-1 MOTIF: kinase domain SITE: 4-287 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 10-18 Thr phosphorylation site {T14} Tyr phosphorylation site {Y15} Tyr phosphorylation site {Y19} ATP-binding site NAME: ATP-binding site SITE: 33-33 aspartate residue {D128} Thr phosphorylation site {T161} Thr-phosphate {T161} binding site EFFECTOR-BOUND: cyclin A BOUND-VIA: cyclin box cyclin A MOTIF: ubiquitination site (destruction box, D-box) SITE: N-TERMINAL FOR-BINDING-OF: ubiquitin PEST region cyclin box EFFECTOR-BOUND: cyclin-dependent kinase-1 BOUND-VIA: binding site MISC-INFO: RECOGNITION-MOTIF :SEQUENCE XK[S*]PX+ XK[T*]PX+

References

  1. Hunt T. Cell biology. Destruction's our delight... Nature. 1991 Jan 10;349(6305):100-1. PMID: 1824721
  2. Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: 1988147
  3. Kemp BE, Pearson RB. Protein kinase recognition sequence motifs. Trends Biochem Sci. 1990 Sep;15(9):342-6. Review. PMID: 2238044

Component-of

molecular complex

Components

cyclin A cyclin-dependent kinase-1 (CDK1), cell division control protein-2 (cdc2), p34 protein kinase or p34cdc2