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CDC45-related protein; cell division cycle 45 S. cerevisiae homolog-like; cell division control protein 45 homolog; PORC-PI-1 (CDC45, CDC45L, CDC45L2, UNQ374/PRO710)
Function:
- required for initiation of chromosomal DNA replication
- associated with ORC2
Structure: belongs to the CDC45 family
Compartment: cytoplasm. nucleus
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- highest levels are found in adult testis & thymus & in fetal liver
- transcript peaks at G1-S phase transition, but total protein remains constant throughout the cell cycle
- expressed in multiple tissues during embryogenesis, including neural crest-derived structures
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 566 aa
MW = 66 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Tyr phosphorylation site {Y130}
Ser phosphorylation site {S144}
Ser phosphorylation site {S148}
Ser phosphorylation site {S151}
Database Correlations
OMIM 603465
UniProt O75419
Pfam PF02724
Entrez Gene 8318
Kegg hsa:8318
References
- UniProt :accession O75419
- NIEHS-SNPs
http://egp.gs.washington.edu/data/cdc45l/