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CDC42 small effector protein 2 (small effector of CDC42 protein 2, CDC42SE2, SPEC2)
Function:
- probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly
- recruited to the activated TCR prior to actin polymerization
- alters CDC42-induced cell shape changes
- in activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse
- may play a role in early contractile events in phagocytosis in macrophages
- interacts with CDC42 (in GTP-bound form)
- interacts weakly with RAC1 & not at all with RHOA
Structure:
- CRIB domain mediates interaction with CDC42
- belongs to the CDC42SE/SPEC family
- contains 1 CRIB domain
Compartment:
- cytoplasm, cell membrane, lipid-anchor
- localizes at the phagocytic cup of macrophages
Expression:
- widely expressed
- expressed at higher level in T lymphocytes
- highly expressed in CCRF-CEM T lymphocytes, Jurkat T lymphocytes, & Raji B lymphocytes (at protein level)
Genetics:
- CDC42SE2 is mapped in the genomic region associated with schizophrenia
General
cytoskeletal protein
Properties
SIZE: entity length = 84 aa
MW = 9 kD
COMPARTMENT: cytoplasm
MOTIF: cysteine residue {C10}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C11}
MODIFICATION: palmitate
COMPARTMENT: membrane
arginine-rich region {20-23}
MOTIF: arginine residue (SEVERAL)
CRIB domain {29-42}
Database Correlations
UniProt Q9NRR3
Pfam PF00786
Kegg hsa:5699
References
UniProt :accession Q9NRR3