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Cdc42 effector protein 5; binder of Rho GTPases 3 (CDC42EP5, BORG3, CEP5)
Function:
1) organization of the actin cytoskeleton
- may act downstream of CDC42 to induce actin filament
2) induces pseudopodia formation in fibroblasts
3) inhibits MAPK8 independently of CDC42 binding
4) controls septin organization, this effect negatively regulated by CDC42
5) interacts with CDC42, GTP-dependent manner
6) interacts with SEPT7
Structure:
- CRIB domain mediates interaction with CDC42
- belongs to the BORG/CEP family
- contains 1 CRIB domain
Compartment:
- endomembrane system, peripheral membrane (putative)
- cytoplasm, cytoskeleton
General
Cdc42 effector protein; binder of Rho GTPases
Properties
SIZE: entity length = 148 aa
MW = 15 kD
COMPARTMENT: cytoplasm
MOTIF: CRIB domain {23-37}
proline-rich region
SITE: 56-87
MOTIF: proline residue (SEVERAL)
alanine-rich region {114-117}
MOTIF: alanine residue (SEVERAL)
Database Correlations
OMIM 609171
UniProt Q6NZY7
Pfam PF00786
Entrez Gene 148170
Kegg hsa:148170
References
UniProt :accession Q6NZY7