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Cdc42 effector protein 4; binder of Rho GTPases 4 (CDC42EP4, BORG4, CEP4)
Function:
1) organization of the actin cytoskeleton
2) induces actin filament assembly leading to cell shape changes
3) induces pseudopodia formation, when overexpressed in fibroblasts
4) may act downstream of CDC42
5) interacts with CDC42 & RHOQ (GTP-dependent)
Structure:
- belongs to the BORG/CEP family
- contains 1 CRIB domain
Compartment:
- endomembrane system; peripheral membrane
- cytoplasm, cytoskeleton
Expression:
- not detected in adult tissues
- may be expressed only in fetal or embryonic tissues
General
Cdc42 effector protein; binder of Rho GTPases
phosphoprotein
Properties
SIZE: entity length = 356 aa
MW = 38 kD
COMPARTMENT: cytoplasm
MOTIF: CRIB domain {27-41}
Ser phosphorylation site {S64}
serine-rich region {70-74}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S109}
Ser phosphorylation site {S138}
Ser phosphorylation site {S141}
Ser phosphorylation site {S142}
Ser phosphorylation site {S174}
Ser phosphorylation site {S292}
Ser phosphorylation site {S295}
Database Correlations
OMIM 605468
UniProt Q9H3Q1
Pfam PF00786
Entrez Gene 23580
Kegg hsa:23580
References
UniProt :accession Q9H3Q1