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Cdc42 effector protein 3; binder of Rho GTPases 2; MSE55-related Cdc42-binding protein (CDC42EP3 BORG2 CEP3)
Function:
1) organization of the actin cytoskeleton
2) induces actin filament assembly leading to cell shape changes
3) induces pseudopodia formation in fibroblasts.
4) may act downstream of CDC42
5) interacts with RHOQ & CDC42 (GTP-dependent)
6) interacts with SEPT7
Structure:
- belongs to the BORG/CEP family
- contains 1 CRIB domain
Compartment: cytoplasm, cytoskeleton, membrane
Expression:
- expressed in heart, weakly in brain
General
Cdc42 effector protein; binder of Rho GTPases
Properties
SIZE: entity length = 254 aa
MW = 28 kD
COMPARTMENT: cytoplasm
MOTIF: CRIB domain {31-45}
Tyr phosphorylation site {Y63}
Ser phosphorylation site {S89}
Ser phosphorylation site {S91}
Ser phosphorylation site {S100}
Ser phosphorylation site {S108}
Database Correlations
OMIM 606133
UniProt Q9UKI2
Pfam PF00786
Entrez Gene 10602
Kegg hsa:10602
References
UniProt :accession Q9UKI2