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Cdc42 effector protein 2; binder of Rho GTPases 1 (CDC42EP2, BORG1, CEP2)
Function:
1) organization of actin cytoskeleton
a) cell shape changes
b) pseudopodia formation in fibroblasts
2) act downstream of CDC42
3) interaction with RHOQ & CDC42 (GRP-dependent)
4) interacts with SEPT7
Structure:
- CRIB domain mediates interaction with CDC42
- belongs to the BORG/CEP family
- contains 1 CRIB domain
Compartment: cytoplasmic & membrane-associated
Expression:
- highly expressed in heart
- weakly expressed in pancreas & liver
General
Cdc42 effector protein; binder of Rho GTPases
phosphoprotein
Properties
SIZE: entity length = 210 aa
MW = 22 kD
COMPARTMENT: cytoplasm
MOTIF: CRIB domain {30-44}
MOTIF: Ser phosphorylation site {S31}
Ser phosphorylation site {S101}
Ser phosphorylation site {S141}
Database Correlations
OMIM 606132
UniProt O14613
Pfam PF00786
Entrez Gene 10435
Kegg hsa:10435
References
- UniProt :accession O14613
- NIEHS-SNPs
http://egp.gs.washington.edu/data/cdc42ep2/