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cdc25 protein
The cdc25 protein catalyzes guanine nucleotide exchange for the ras1 & ras2 proteins, activators of yeast adenylate cyclase. Some confusion here. In fission yeast, drosophila, & humans, the product of CDC25 gene (p54cdc25) promotes G2 -> M transition via dephosphorylation of p34cdc2 (CDK1) in MPF or yeast equivalent (ref 2)
Related
M-phase inducer phosphatase or CDC25
General
fungus-specific molecule
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
COMPARTMENT: cytoplasm
CELL: Saccharomyces cerevisiae
KINGDOM: plant
DIVISION: EUMYCOPHYTA
cell nucleus
CELL: Saccharomyces cerevisiae
KINGDOM: plant
DIVISION: EUMYCOPHYTA
MOTIF: src homology 3 [SH3] domain
SITE: N-TERMINAL
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
binding site
FOR-BINDING-OF: ras subfamily protein
MOTIF: active site
domain (3)
HOMOLOGY: ras guanine nucleotide releasing factor 1
son of sevenless homolog protein (SOS)
cdc25 protein
Sdc25 protein
References
- Bourne HR et al
Ras proteins, Some signal developments
Nature 348:125 1990
PMID: 2175395
- Strausfeld U et al
Dephosphorylation and activation of a p34cdc2/cyclin B
complex in vitro by human CDC25 protein.
Nature. 1991 May 16;351(6323):242-5.
PMID: 1828290
- Boguski MS & McCormick F
Proteins regulating Ras and its relatives.
Nature 366:643 1993
PMID: 8259209