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M-phase inducer phosphatase or CDC25

Function: - CDC25 phosphatases activate cell division kinases throughout the cell cycle Comparative biology: - in fission yeast, drosophila, & humans, the product of CDC25 gene (p80cdc25 in humans & p54cdc25 in yeast) promotes G2 -> M transition via dephosphorylation of p34cdc2 (CDK1) in MPF or yeast equivalent [1]

Interactions

molecular events

Related

cdc25 protein ras guanine nucleotide releasing factor 1; Ras-specific guanine nucleotide-releasing factor 1; Ras-GRF1; guanine nucleotide-releasing factor 1; Ras-specific nucleotide exchange factor CDC25 (RASGRF1, CDC25, GNRP, GRF1)

Specific

M-phase inducer phosphatase-1 (dual-specificity phosphatase Cdc25A, CDC25A) M-phase inducer phosphatase-2 (dual specificity phosphatase Cdc25B, CDC25B, CDC25HU2) M-phase inducer phosphatase-3 (dual specificity phosphatase Cdc25C, CDC25C)

General

dual specificity phosphatase nuclear protein

Properties

SIZE: MW = 80 kD COMPARTMENT: cell nucleus CELL-CYCLE: G2 MOTIF: S/T phosphorylation site {N-TERMINAL} active site MOTIF: HC motif STATE: active state

References

  1. Strausfeld U et al Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. Nature. 1991 May 16;351(6323):242-5. PMID: 1828290
  2. Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell. 1991 Oct 4;67(1):197-211. PMID: 1913817
  3. Dunphy WG, Kumagai A. The cdc25 protein contains an intrinsic phosphatase activity. Cell. 1991 Oct 4;67(1):189-96. PMID: 1655274
  4. Keyse SM, Ginsburg M. Amino acid sequence similarity between CL100, a dual- specificity MAP kinase phosphatase and cdc25. Trends Biochem Sci. 1993 Oct;18(10):377-8. Review. PMID: 8256285