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cell division cycle protein 20 homolog; p55CDC (CDC20)
Function:
- participates with HCDH1 in activation of anaphase promoting complex
- required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C)
- may confer substrate specificity on the complex
- regulated by MAD2L1
- in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive & in anaphase the CDC20-APC/C binary complex is active in degrading substrates
- protein modification; protein ubiquitination
- phosphorylated during mitosis, probably by maturation promoting factor (MPF)
- phosphorylated by BUB1 at Ser-41, Ser-72, Ser-92, Ser-153, Thr-157 & Ser-161
- ubiquitinated & degraded by the proteasome during spindle assembly checkpoint
- found in a complex with CDC20, CDC27, SPATC1 & TUBG1
- interacts with SPATC1 (putative)
- interacts with MAD2L1 & BUB1B
- phosphorylated form interacts with APC/C
- interacts with NINL
- interacts with MAD2L1
Structure:
- belongs to the WD repeat CDC20/Fizzy family
- contains 7 WD repeats
Expression:
- synthesis is initiated at G1/S, protein level
- peaks in M phase & protein is abruptly degraded at M/G1 transition
General
nuclear protein
phosphoprotein
WD repeat protein family
Properties
SIZE: entity length = 499 aa
MW = 55 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S41}
Thr phosphorylation site {T70}
Ser phosphorylation site {S72}
Ser phosphorylation site {S92}
Thr phosphorylation site {T106}
Ser phosphorylation site {S153}
Thr phosphorylation site {T157}
Ser phosphorylation site {S161}
WD repeat {182-221}
WD repeat {224-263}
WD repeat {266-303}
WD repeat {307-346}
WD repeat {353-395}
WD repeat {397-438}
WD repeat {441-480}
Database Correlations
OMIM 603618
UniProt Q12834
Pfam PF00400
Entrez Gene 991
Kegg hsa:991
References
- UniProt :accession Q12834
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/CDC20ID40003ch1p34.html
- NIEHS-SNPs
http://egp.gs.washington.edu/data/cdc20/