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CD99; T-cell surface glycoprotein E2; E2 antigen; protein MIC2; 12E7 (CD99, MIC2, MIC2X, MIC2Y)
Function:
- role in T-cell adhesion processes
- involved in spontaneous rosette formation with erythrocytes
Structure:
- extensively O-glycosylated
- belongs to the CD99 family
Compartment:
- membrane; single-pass type 1 membrane protein (putative)
Alternative splicing: named isoforms=2
Expression:
- ovarian granulosa cells
- pancreatic islet cells
- infant thymus
- Sertoli cells
Pathology:
- associated with EWS-FLI1 fusion transcript, t(11;22)(q24;q12) causing FLI-1 protein overexpression
- tumors staining positive with antibody
- T cell acute lymphoblastic lymphoma
- calcifying aponeurotic fibroma
- Ewing's sarcoma/PNET (95% sensitive, membranous staining, other tumors cytoplasmic)
- gastrointestinal stromal tumor
- intraabdominal desmoplastic small round cell tumor (23-35%)
- leukemia cutis
- nuchal fibromas
- perineuroma (myxoid sclerosing type)
- rhabdomyosarcoma (membranous staining)
- sinonasal undifferentiated carcinoma (rare)
- small cell carcinomas of lung (rare)
- solitary fibrous tumor
- synovial sarcoma
- Wilm's tumors (some)
- endometrial stromal tumors with sex cord differentiation
- adult neuroblastoma stain negatively with antibody
Genetics:
- the gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X & Y chromosomes
Related
CD99 Ag in tissue
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
Properties
SIZE: entity length = 185 aa
MW = 19 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-22}
transmembrane domain {123-147}
Database Correlations
OMIM correlations
UniProt P14209
Entrez Gene 4267
Kegg hsa:4267
References
- UniProt :accession P14209
- http://www.pathologyoutlines.com/cdmarkers.html
11 June 2005