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CD9; p24; leukocyte antigen MIC3; Motility-related protein; MRP-1; tetraspanin-29; Tspan-29; 5H9 antigen; cell growth-inhibiting gene 2 protein (MIC3, TSPAN29, GIG2)
Function:
- role in platelet activation & aggregation
- regulates paranodal junction formation
- required for gamete fusion
- involved in cell adhesion, cell motility
- forms both disulfide-linked homodimers & higher homooligomers as well as heterooligomers with other members of the tetraspanin family
- associates with CR2/CD21 & with PTGFRN/CD9P1
- interacts directly with IGSF8
Structure:
- belongs to the tetraspanin (TM4SF) family
- protein exists in three forms with molecular masses between 22 & 27 kD, & is known to carry covalently linked fatty acids
Compartment: membrane
Expression:
- expressed by a variety of hematopoietic & epithelial cells
- pre B cells
- subset of B cells
- T cells
- macrophages
- platelets
- eosinophils
- basophils
- megakaryocytes
- endothelial cells
- brain
- peripheral nerve
- vascular smooth muscle
- cardiac muscle
- epithelia
Pathology:
- involved in tumor metastasis
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
tetraspanin (transmembrane-4-superprotein)
Properties
SIZE: entity length = 228 aa
MW = 25 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {2-12}
MOTIF: cysteine residue {C9}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {13-33}
exoplasmic loop {34-55}
MOTIF: N-glycosylation site {N52}
N-glycosylation site {N53}
transmembrane domain {56-76}
cytoplasmic loop {77-87}
MOTIF: cysteine residue {C78}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C79}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C87}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {88-111}
exoplasmic loop {112-195}
transmembrane domain {196-221}
MOTIF: cysteine residue {C218}
MODIFICATION: palmitate
COMPARTMENT: membrane
cysteine residue {C219}
MODIFICATION: palmitate
COMPARTMENT: membrane
cytoplasmic domain {222-228}
Database Correlations
OMIM 143030
UniProt P21926
Pfam PF00335
Entrez Gene 928
Kegg hsa:928
References
- UniProt :accession P21926
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Entrez Gene :accession 928