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CD83 antigen; cell surface protein HB15; B-cell activation protein (CD83)
Function:
- may play a role in antigen presentation or cellular interactions that follow lymphocyte activation
Structure:
- monomer
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: membrane
Expression:
- expressed by activated lymphocytes, Langerhans cells & interdigitating reticulum cells
- marker for dendritic cells
- non-follicular dendritic cells
- circulating dendritic cells
- interdigitating dendritic cells within lymphoid tissues
- Langerhan's cells
- in vitro generated dendritic cells
- thymic dendritic cells
- weak reactivity with some lymphoblastoid cell lines & with some germinal center B cells in vivo
Pathology:
- expressed in inflammatory infiltrates of Churg-Strauss syndrome myocarditis
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
immunoglobulin superfamily protein
Properties
SIZE: entity length = 205 aa
MW = 23 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
immunoglobulin superfamily domain {28-114}
MOTIF: cysteine residue {C35}
MODIFICATION: cysteine residue {C107}
N-glycosylation site {N79}
N-glycosylation site {N96}
cysteine residue {C107}
MODIFICATION: cysteine residue {C35}
N-glycosylation site {N117}
transmembrane domain {145-166}
Database Correlations
OMIM 604534
UniProt Q01151
Pfam PF00047
Entrez Gene 9308
Kegg hsa:9308
References
- UniProt :accession Q01151
- Entrez Gene :accession 9308
- Protein Reviews on the Web
http://mpr.nci.nih.gov/prow/guide/261901699_g.htm
- http://www.pathologyoutlines.com/cdmarkers.html
20 May 2003