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CD72; B-cell differentiation antigen CD72; Lyb-2 (CD72)
Function:
- may control B cell proliferation & differentiation
- associates with CD5
Structure:
- homodimer; disulfide-linked
- contains 1 C-type lectin domain
Compartment: plasma membrane
Expression:
- exclusively B cells
- pre-B-cells & B-cells but not terminally differentiated plasma cells
Pathology:
- expressed in hairy cell leukemia
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
lectin
Properties
SIZE: entity length = 359 aa
MW = 40 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {96-116}
N-glycosylation site {N136}
C-type lectin {232-352}
MOTIF: cysteine residue {C233}
MODIFICATION: cysteine residue {C244}
cysteine residue {C244}
MODIFICATION: cysteine residue {C233}
cysteine residue {C261}
MODIFICATION: cysteine residue {C350}
cysteine residue {C325}
MODIFICATION: cysteine residue {C342}
cysteine residue {C342}
MODIFICATION: cysteine residue {C325}
cysteine residue {C350}
MODIFICATION: cysteine residue {C261}
Database Correlations
OMIM 107272
UniProt P21854
Pfam PF00059
Entrez Gene 971
Kegg hsa:971
References
- UniProt :accession P21854
- http://www.pathologyoutlines.com/cdmarkers.html
20 January 2003
- Entrez Gene :accession 971
- Functional glycomics gateway - glycan binding Note: CD72
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_237