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CD7; T-cell antigen CD7; GP40; T-cell leukemia antigen; TP41
Function:
- unknown
- interacts with SECTM1
Structure: contains 1 Ig-like (immunoglobulin-like) domain
Compartment: membrane
Expression:
- present on most T-cells
a) mature peripheral T cells ~85%
b) most post-thymic T cells
- most NK cells
- some myeloid cells
Pathology:
- expressed in:
a) T-cell ALL
b) AML (especially AML-M4, AML-M5)
c) chronic myelogenous leukemia
- adult T cell leukemia/lymphoma, Sezary syndrome, B-cell ALL show negative staining with antibody
Related
CD7 Ag in tissue
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
lipoprotein
Properties
SIZE: entity length = 240 aa
MW = 25 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-25}
immunoglobulin superfamily domain {26-130}
MOTIF: cysteine residue {C35}
MODIFICATION: cysteine residue {C142}
N-glycosylation site {N45}
cysteine residue {C48}
MODIFICATION: cysteine residue {C114}
N-glycosylation site {N96}
cysteine residue {C114}
MODIFICATION: cysteine residue {C48}
cysteine residue {C142}
MODIFICATION: cysteine residue {C35}
4 X 9 AA tandem repeats, potential spacer function {145-180}
MOTIF: consensus repeat {145-153}
consensus repeat {154-162}
consensus repeat {163-171}
consensus repeat {172-180}
transmembrane domain {181-201}
MOTIF: cysteine residue {C198}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 186820
UniProt P09564
Pfam PF07686
Entrez Gene 924
Kegg hsa:924
References
- UniProt :accession P09564
- Cotran et al Robbins Pathologic Basis of Disease,
W.B. Saunders Co, Philadelphia, PA 1989 pg 165
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Entrez Gene :accession 924