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CD69; early activation antigen CD69; early T-cell activation antigen p60; GP32/28; Leu-23; MLR-3; EA1; BL-AC/P26; activation inducer molecule; AIM (CD69)
Function:
- role in lymphocyte proliferation & functions as a signal transmitting receptor in lymphocytes, natural killer cells, & platelets
- earliest inducible cell surface glycoprotein in lymphoid activation
- constitutive Ser/Thr phosphorylation in both mature thymocytes & activated T-lymphocytes
Structure:
- homodimer; disulfide-linked
- contains 1 C-type lectin domain
Compartment:
- plasma membrane
Expression:
- activated T cells, B cells NK cells
- neutrophils
- eosinophils
- epidermal Langerhans cells
Pathology:
- expressed in T cells in rheumatoid arthritis, viral hepatitis & autoimmune thyroid disorders
Related
CD69 cells in blood
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
lectin
Properties
SIZE: entity length = 199 aa
MW = 23 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {41-61}
C-type lectin {92-195}
MOTIF: cysteine residue {C113}
MODIFICATION: cysteine residue {C194}
N-glycosylation site {N166}
cysteine residue {C173}
MODIFICATION: cysteine residue {C186}
cysteine residue {C186}
MODIFICATION: cysteine residue {C173}
cysteine residue {C194}
MODIFICATION: cysteine residue {C113}
Database Correlations
OMIM 107273
UniProt Q07108
Pfam PF00059
Entrez Gene 969
Kegg hsa:969
References
- UniProt :accession Q07108
- http://www.pathologyoutlines.com/cdmarkers.html
20 January 2003
- Entrez Gene :accession 969
- Functional glycomics gateway - glycan binding - Note: CD69
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_235