Search
CD6; T-cell differentiation antigen CD6; T12; TP120
Function:
- role in cell adhesion
- binds to CD166
- after T-cell activation, becomes hyperphosphorylated on Ser & Thr & phosphorylated on Tyr
Structure:
- contains intrachain disulfide bond(s)
- contains 3 SRCR domains
Compartment: membrane
Alternative splicing: named isoforms=5
- CD6A, CD6B, CD6C, CD6D, CD6E
Expression:
- thymocytes
a) immature thymocytes - low levels
b) mature thymocytes - high levels
- mature T-cells
- subset of B-cells known as B-1 cells
- some cells in the brain
Interactions
molecular events
General
adhesion receptor
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
Properties
SIZE: entity length = 668 aa
MW = 72 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-17}
N-glycosylation site {N28}
SRCR 1 {45-156}
MOTIF: N-glycosylation site {N49}
cysteine residue {C70}
MODIFICATION: cysteine residue {C144}
cysteine residue {C83}
MODIFICATION: cysteine residue {C155}
N-glycosylation site {N112}
N-glycosylation site {N118}
cysteine residue {C129}
MODIFICATION: cysteine residue {C137}
cysteine residue {C137}
MODIFICATION: cysteine residue {C129}
cysteine residue {C144}
MODIFICATION: cysteine residue {C70}
cysteine residue {C155}
MODIFICATION: cysteine residue {C83}
SRCR 2 {161-260}
MOTIF: cysteine residue {C186}
MODIFICATION: cysteine residue {C249}
cysteine residue {C199}
MODIFICATION: cysteine residue {C259}
N-glycosylation site {N229}
cysteine residue {C230}
MODIFICATION: cysteine residue {C240}
cysteine residue {C240}
MODIFICATION: cysteine residue {C230}
cysteine residue {C249}
MODIFICATION: cysteine residue {C186}
cysteine residue {C259}
MODIFICATION: cysteine residue {C199}
SRCR 3 {265-361}
MOTIF: cysteine residue {C290}
MODIFICATION: cysteine residue {C350}
cysteine residue {C303}
MODIFICATION: cysteine residue {C360}
cysteine residue {C330}
MODIFICATION: cysteine residue {C340}
N-glycosylation site {N339}
cysteine residue {C340}
MODIFICATION: cysteine residue {C330}
N-glycosylation site {N345}
cysteine residue {C350}
MODIFICATION: cysteine residue {C290}
cysteine residue {C360}
MODIFICATION: cysteine residue {C303}
N-glycosylation site {N368}
transmembrane domain {403-423}
Database Correlations
OMIM 186720
UniProt P30203
Pfam PF00530
Entrez Gene 923
References
- UniProt :accession P30203
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
Component-of
molecular complex