CD5 antigen-like (SP-alpha, CT-2, lymphocyte antigen CD5-like, IgM-associated peptide, CD5L)

Function: 1) regulation of the immune system (putative) 2) inhibitor of apoptosis (putative) 3) associated with IgM Compartment: secreted Expression: - expressed in spleen, lymph node, thymus, bone marrow, fetal liver - not expressed in non-lymphoid tissues

Properties

SIZE: MW = 38 kD entity length = 347 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-19} SRCR 1 {24-125} MOTIF: cysteine residue {C49} MODIFICATION: cysteine residue {C114} cysteine residue {C62} MODIFICATION: cysteine residue {C124} cysteine residue {C96} MODIFICATION: cysteine residue {C106} cysteine residue {C106} MODIFICATION: cysteine residue {C96} cysteine residue {C114} MODIFICATION: cysteine residue {C49} cysteine residue {C124} MODIFICATION: cysteine residue {C62} SRCR 2 {138-239} MOTIF: cysteine residue {C163} MODIFICATION: cysteine residue {C228} cysteine residue {C176} MODIFICATION: cysteine residue {C238} cysteine residue {C208} MODIFICATION: cysteine residue {C218} cysteine residue {C218} MODIFICATION: cysteine residue {C208} cysteine residue {C228} MODIFICATION: cysteine residue {C163} cysteine residue {C238} MODIFICATION: cysteine residue {C176} SRCR 3 {244-346} MOTIF: cysteine residue {C269} MODIFICATION: cysteine residue {C335} cysteine residue {C282} MODIFICATION: cysteine residue {C345} cysteine residue {C315} MODIFICATION: cysteine residue {C325} cysteine residue {C325} MODIFICATION: cysteine residue {C315} cysteine residue {C335} MODIFICATION: cysteine residue {C269} cysteine residue {C345} MODIFICATION: cysteine residue {C282}

Database Correlations

OMIM 602592 UniProt O43866 Pfam PF00530

References

UniProt :accession O43866