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CD53; leukocyte surface antigen CD53; cell surface glycoprotein CD53; tetraspanin-25; Tspan-25 (MOX44, TSPAN25)
Function:
- may be involved in growth regulation in hematopoietic cells
Structure: belongs to the tetraspanin (TM4SF) family
Compartment: membrane
Expression:
- pan-leukocyte marker
- B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes & peripheral T-cells
- platelets, red blood cells & non-hematopoietic cells stain negatively with antibody
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
tetraspanin (transmembrane-4-superprotein)
Properties
SIZE: entity length = 219 aa
MW = 24 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-11}
transmembrane domain {12-32}
exoplasmic loop {33-54}
transmembrane domain {55-69}
cytoplasmic loop {70-80}
transmembrane domain {81-106}
exoplasmic loop {107-181}
MOTIF: N-glycosylation site {N129}
N-glycosylation site {N148}
transmembrane domain {182-206}
cytoplasmic domain {207-219}
Database Correlations
OMIM 151525
UniProt P19397
Pfam PF00335
Entrez Gene 963
Kegg hsa:963
References
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Entrez Gene :accession 963
- UniProt :accession P19397