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CD5; T-cell surface glycoprotein CD5; lymphocyte antigen T1/Leu-1 (CD5, LEU1)
Function:
- may act as a receptor in regulating T-cell proliferation
- interacts with CD72/LYB-2
Structure: contains 3 SRCR domains
Compartment: membrane
Expression:
- B-cells of mantle zone
- B-cells in peritoneal & pleural cavities
- almost all T-cells
Pathology:
- expressed in
a) B cell CLL/small lymphocytic lymphoma
b) mantle cell lymphoma
c) hairy cell leukemia
d) most T-cell malignancies
e) thymic carcinomas (spindle cell thymomas negatively stain for antibody)
Related
CD5 Ag in tissue
CD5 cells in specimen
PAX5+CD5 Ag in tissue
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 495 aa
MW = 55 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-24}
SRCR 1 {35-133}
MOTIF: cysteine residue {C60}
MODIFICATION: cysteine residue {C125}
cysteine residue {C81}
MODIFICATION: cysteine residue {C132}
cysteine residue {C107}
MODIFICATION: cysteine residue {C117}
N-glycosylation site {N116}
cysteine residue {C117}
MODIFICATION: cysteine residue {C107}
cysteine residue {C125}
MODIFICATION: cysteine residue {C60}
cysteine residue {C132}
MODIFICATION: cysteine residue {C81}
SRCR 2 {159-268}
MOTIF: cysteine residue {C201}
MODIFICATION: cysteine residue {C267}
N-glycosylation site {N241}
cysteine residue {C244}
MODIFICATION: cysteine residue {C250}
cysteine residue {C250}
MODIFICATION: cysteine residue {C244}
cysteine residue {C267}
MODIFICATION: cysteine residue {C201}
SRCR 3 {276-368}
MOTIF: cysteine residue {C301}
MODIFICATION: cysteine residue {C360}
cysteine residue {C316}
MODIFICATION: cysteine residue {C367}
cysteine residue {C342}
MODIFICATION: cysteine residue {C350}
cysteine residue {C350}
MODIFICATION: cysteine residue {C342}
cysteine residue {C360}
MODIFICATION: cysteine residue {C301}
cysteine residue {C367}
MODIFICATION: cysteine residue {C316}
transmembrane domain {373-402}
Ser phosphorylation site {S439}
Tyr phosphorylation site {Y453}
Ser phosphorylation site {S460}
Database Correlations
OMIM 153340
UniProt P06127
Pfam PF00530
Entrez Gene 921
Kegg hsa:921
References
- Cotran et al Robbins Pathologic Basis of Disease,
5th ed. W.B. Saunders Co, Philadelphia, PA 1994 pg 637
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Entrez Gene :accession 921
- UniProt :accession P06127