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CD48; B-lymphocyte activation marker BLAST-1; BCM1 surface antigen; Leukocyte antigen MEM-102; TCT.1 (BCM1, BLAST1)
Function:
- associates with/activates lck [1]
- ligand for CD2
- might facilitate interaction between activated lymphocytes
- probably involved in regulating T-cell activation
Structure:
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: cell membrane; lipid-anchor, GPI-anchor
Expression:
- most leukocytes
- activated lymphocytes
- neutrophils & platelets stain negatively with antibody
Pathology:
- numbers of CD48+ lymphocytes decreased in paroxysmal nocturnal hemoglobinuria
Interactions
molecular events
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glypiated protein
Properties
SIZE: entity length = 243 aa
MW = 28 kD
COMPARTMENT: plasma membrane
CELL-REGION: apical region
CELL: epithelial cell
MOTIF: signal sequence {1-26}
immunoglobulin superfamily domain {29-127}
MOTIF: N-glycosylation site {N40}
N-glycosylation site {N44}
N-glycosylation site {N104}
immunoglobulin superfamily domain {132-212}
MOTIF: cysteine residue {C154}
MODIFICATION: cysteine residue {C196}
N-glycosylation site {N162}
N-glycosylation site {N189}
cysteine residue {C196}
MODIFICATION: cysteine residue {C154}
glycosyl phosphatidylinositol [GPI] membrane anchor {N220}
Database Correlations
OMIM 109530
UniProt P09326
Entrez Gene 962
Kegg hsa:962
References
- Bolen JB, Rowley RB, Spana C, Tsygankov AY.
The Src family of tyrosine protein kinases in hemopoietic
signal transduction.
FASEB J. 1992 Dec;6(15):3403-9. Review.
PMID: 1281458
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Entrez Gene :accession 962
- UniProt :accession P09326
Component-of
molecular complex