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CD45 (leukocyte common antigen T200 or protein tyrosine phosphatase, receptor type, C polypeptide)
Function:
- required for T & B cell antigen receptor-mediated activation
Alternative splicing: at least 8 isoforms
Expression:
- present on all leukocytes
- different isoforms are expressed in different subsets of hematopoietic cells:
a) CD45RA: naive/resting T cells, medullary thymocytes
- expressed in hematopoietic cells, stronger staining in lymphocytes
- expressed in red blood cells, non-hematopoietic cells
- in the CNS, CD45 is a marker of microglia [4]
Pathology:
- lymphoplasmacytic lymphoma, lymphoblastic lymphoma, anaplastic lymphoma, multiple myeloma
- Reed-Sternberg cells stain negatively with antibody
Interactions
molecular events
Related
CD45 Ag in tissue
CD45RB Ag in tissue
leukocyte common Ag (CD45) in tissue
Specific
CD45RA
CD45RO or UCHL-1
General
adhesion receptor
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
tyrosine phosphatase, receptor type
Properties
COMPARTMENT: plasma membrane
CELL: leukocyte
STATE: active state
MOTIF: focal adhesion site
O-glycosylation site (MANY)
N-glycosylation site (MANY)
membrane region
active site
MOTIF: HC motif
Database Correlations
OMIM 151460
UniProt P08575
Entrez Gene 5788
KEGG correlations
References
- Cotran et al Robbins Pathologic Basis of Disease,
W.B. Saunders Co, Philadelphia, PA 1989 pg 165
- Webb DS et al
LFA-3, CD44, and CD45: physiologic triggers of human monocyte
TNF and IL-1 release.
Science 249:1295 1990
PMID: 1697984
- http://www.pathologyoutlines.com/cdmarkers.html
15 October 2002
- Wilcock et al, American Aging Association, 33rd Annual
meeting, June 4-7, 2004